METHOD OF OPTICAL PURIFICATION OF ENANTIMER-ENRICHED BENZIMIDAZOLE DERIVATIVES Russian patent published in 2000 - IPC

Abstract RU 2144031 C1

FIELD: organic chemistry and technology. SUBSTANCE: invention relates to a method of optical purification of benzimidazole derivatives of the formulas (Ia) , (Ib) , (Ic) , (Id) , (Ie) . Method involves treatment of enantiomer-enriched preparation of any compound of the formulas (Ia-Ie) to obtain (+)- or (-)-enantiomer with a solvent followed by selective precipitation of racemate of the above indicated compounds. Precipitated racemate is filtered off, a solvent is removed and a single enantiomer of improved optical purity is obtained. Method does not require treatment of compounds (Ia-Ie) with reagents. EFFECT: simplified method, improved optical purity. 19 cl, 16 ex

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RU 2 144 031 C1

Authors

Fon Unge Sverker

Dates

2000-01-10Published

1996-06-26Filed