PEPTIDE USED FOR INHIBITION OF PEPSIN RELEASE, PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, peptides, pharmacy. SUBSTANCE: invention describes the novel synthetic peptides of the general formula (I): A₁-A₂-A₃-X where A₁ means L- or D-Thr or one of the following amino acid sequences where at least one amino acid radical can be in D-configuration: Val-Thr, Pro-Val-Thr, Arg-Pro-Val-Thr, Glu-Arg-Pro-Val-Thr, His-Glu-Arg-Pro-Val-Thr, Gln-His-Glu-Arg-Pro-Val-Thr, Leu-Gln-His-Glu-Arg-Pro-Val-Thr, Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr, Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr, Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr, Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr, Pro-Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr or Glu-Pro-Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Arg-Pro-Val-Thr; A₂ means Lys-Pro-Gln-Ala where at least one amino acid radical can be in D-configuration; A₃ means covalent bond and X means hydroxy-, amino-, alkylamino-group being the indicated peptide of the formula (I) has at least one amino acid radical in D-configuration and can has one or multiple similar or different protective groups, or their pharmaceutically acceptable salts. Invention describes also a pharmaceutical composition based on compounds of the formula (I) that inhibits pepsin release. EFFECT: new peptides indicated above, enhanced effectiveness of pepsine release. 24 cl, 6 tbl, 2 ex