FIELD: medicine, more particular preparation of cardiovascular medicinals. SUBSTANCE: described are new alcohol nitrates of general formula I: R′C(O)N(R″)(CH2)nC(NO2)2CH2N(NO2)(CH2)mONO2 (1) wherein R′,R″, n and m are as defined in claims, and method of preparing thereof by reaction of nitration of 3- acylaminodinitroalkyl)tetrahydro-1,3-oxazoles and oxazines. Also described are new intermediate compounds, e.g. 3-(acylaminodinitroalkyl)-tetrahydro-1,3-oxazoles and oxazines of general formula II: wherein R′,R″, n and m are as defined in claims, and method of preparing thereof. EFFECT: more efficient preparation method. 8 cl, 6 ex, 2 tbl
Title | Year | Author | Number |
---|---|---|---|
N-ALKANOLSUCCINAMIDE OR IMIDE NITRATES, METHOD OF PREPARATION THEREOF, N-ALKANOLSUCCINAMIDES OR IMIDES | 1996 |
|
RU2102380C1 |
SUCCINIC ACID DERIVATIVES, METHOD OF PREPARING SAME, INTERMEDIATE COMPOUNDS FOR SYNTHESIS THEREOF, AND METHOD OF PREPARING INTERMEDIATE COMPOUNDS | 1997 |
|
RU2125040C1 |
AMIDOALKANOLNITRATES AND METHOD OF PREPARATION THEREOF | 1998 |
|
RU2147301C1 |
3-NITRO-3-AZAALKANOL-2-ETHERS AND METHOD OF PREPARING THEREOF | 1998 |
|
RU2161602C2 |
METHOD OF PREPARING N-(2-NITROXYETHYL)NICOTINEAMIDE | 1998 |
|
RU2147577C1 |
CATALYST SYSTEM FOR OLIGOMERIZATION OF ETHYLENE INTO LINEAR ALPHA-OLEFINS | 1997 |
|
RU2117012C1 |
METHOD FOR PRODUCING ORGANIC NITRO COMPOUNDS | 2016 |
|
RU2611009C1 |
METHOD FOR PRODUCING PRIMARY ALIPHATIC NITRAMINES | 2016 |
|
RU2610282C1 |
PROCESS OF MANUFACTURE OF CONDUCTIVE POLYMER COAT ON SUBSTRATE | 1992 |
|
RU2035803C1 |
STRAIN OF BACTERIUM PSEUDOMONAS PUTIDA PRODUCING EXTRACELLULAR PETROLEUM-SOLUBLE AGENT AND NUTRIENT MEDIUM FOR ITS CULTURING | 1996 |
|
RU2112798C1 |
Authors
Dates
2000-03-10—Published
1998-04-22—Filed