FIELD: organic chemistry, aminoheterocyclic compounds. SUBSTANCE: invention relates to the method of synthesis of the novel compound - 3-ethyl-5- -methyl(±)2-[(2-aminoethoxy)-methyl] -4-(2-chlorophenyl)-1,4- -dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfo-nate. For synthesis of indicated compound 3-ethyl-5-methyl- -(6-8oC)2-[(2-N-3-phenylmethylamino)-ethoxymethyl] -4-(2-chloro- -phenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate is mixed with hydrochloric acid solution in dioxane and stirred. Then benzenesulfoacid solution in acetone is added, stirred again, water is added, cooled and kept at 6-8 C for 8-12 h. EFFECT: simplified method, increased yield in technology of medicinal forms. 4 cl
| Title |
Year |
Author |
Number |
| METHOD OF PREPARING MONOBENZOSULFONATE OF 2-[(2- AMINOETHOXY) METHYL -4- (2-CHLOROPHENYL)-1,4-DIHYDRO-6- METHYL]-3,5-PYRIDINE DICARBOXYLIC ACID 3-ETHYL-5-METHYL ESTER |
1999 |
- Shrikkhande Atul Anant
- Doshi Madkhukant Mansukkhlal
- Modi Shirish Bkhagvanlal
|
RU2142942C1 |
| METHOD FOR PRODUCTION OF 3-ETHYL-5-METHYL-(±)2/(2-AMINOETHOXY)-METHYL-4-(2-CHLOROPHENYL)-1,4- -DIHYDRO-6-METHYL-3,5-PYRIDINE CARBOXYLATE MONOBENZOATE AND INTERMEDIATE FOR THEM |
1993 |
- Borut Furlan[Si]
- Anton Chopar[Si]
- Alenka Jerikha[Si]
|
RU2105759C1 |
| METHOD OF SYNTHESIS OF 3-ETHYL-5-METHYL-2-(2-AMINOETHOXYMETHYL)- -4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDRO-3,5-PYRIDINE DICARBO-XYLATE AND BENZENESULFOACID SALT (AMLODIPINE BEZYLATE) |
1998 |
- Bozhing Daniehl'
- Laks Kovan'I D'Erd'I
- Shimig D'Jula
- Kratsnai D'Erd'
- Blashko Gabor
- Tomp Peter
- Nad' Kalman
- Donat Veretskei D'Erd'I
- Nemet Gabor
- Nemet Norbert
|
RU2163597C2 |
| AMLODIPIN BENZOLSULFONATE PREPARATION METHOD |
2002 |
|
RU2221784C1 |
| METHOD OF PRODUCING BENZOSULFONATE SALT OF 3-ETHYL-5-METHYL ESTER OF 2-(2-AMINOETHYMETHYL)-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOLIC ACID |
0 |
- Edvard Devison
- Dzhejms Ingram Vells
|
SU1498388A3 |
| METHOD OF PREPARING AMLODIPINE BEZYLATE |
1999 |
|
RU2173685C2 |
| METHOD OF PREPARING 3-ETHYL-5-METHYL ESTER OF 2-[2-N-(PHTHALIMIDO)ETHOXYMETHYL]- 4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID |
1999 |
- Atul Anant Shrikkhande
- Madkhukant Makhsukkhlal Doshi
- Shirish Bkhagvanlal Modi
|
RU2161156C1 |
| STABLE COMBINED PHARMACEUTICAL COMPOSITION |
2009 |
- Vagner Laslo
- Zhigmond Zhol'T
- Ujfalushshi D'Erd'
- Leventisne Khusar Magdol'Na
- Tonka-Nad' Peter
- Bartsai Ehrzhebet
- Gora Laslone
- Seletski Ehdit
- Fjulep Agnesh
|
RU2549437C2 |
| (S)-(-)-AMLODIPINE CAMSYLATE OR ITS HYDRATE AND PHARMACEUTICAL COMPOSITION INCLUDING THEM |
2007 |
- Li Dzaekheon
- Li Moon Sub
- Jang Veon Ki
- Joo Dzaekho
- Li Dzae-Chul
- Choi Chang-Dzu
- Kim Khan Kiong
- Chang Jang-Kil
- Li Gvansun
|
RU2403241C1 |
| METHOD OF PRODUCING DERIVATIVES OF 1,4-DIHYDROPYRIDINE OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Simon Frazer Kempbell
- Piter Edvard Kross
- Dzhon Kendrik Stabbz
|
SU1238730A3 |
