FIELD: medicine, oncology, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition showing an antitumor activity and containing themozolomid: 8-carbamoyl-3-methylimidazo-[5,1-d]-1,2,3,5-tetrazine-4-(3H)-one as an active component and inhibitor of O6-alkylguanine-DNA-alkyltransferase at ratio from 1:1 to 1:20.000. Also, pharmaceutical composition has at least one pharmaceutically acceptable carrier. Inhibitor is taken among the group including O6-alkylguanines, O6-arylguanines and O6-benzylated guanines, guanosines and 2'-deoxyguanosines. Method of preparing the pharmaceutical composition involves mixing themozolomid with inhibitor of O6-alkylguanine-DNA-alkyl-transferase and pharmaceutically acceptable carrier. EFFECT: enhanced antitumor activity of composition. 4 cl, 5 dwg, 2 tbl, 6 ex
| Title |
Year |
Author |
Number |
| DERIVATIVES OF O-ALKYLGUANINE AND PHARMACEUTICAL COMPOSITION |
1994 |
- Tomas Brajen Gamil'Ton Makmurri
- Robert Stehnli Makehlkhinni
- Dzhoan Ehlizabet Makkormik
- Roderik Kh'Ju Ehlder
- Dzhejn Kelli
- Dzheffri Pol Margison
- Dzhozef Ehntoni Rafferti
- Amanda Dzhin Vatson
- Mark Ehndrju Villington
|
RU2154646C2 |
| METHOD OF CELL SELECTION IN VIVO BY USING LYSOMUSTINE |
2010 |
- Rozov Fedor Nikolaevich
- Levit Galina L'Vovna
- Krasnov Viktor Pavlovich
- Beljavskij Aleksandr Vadimovich
|
RU2425149C1 |
| RAPAMYCIN TARGET INHIBITOR IN MAMMALIAN CELLS, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
2019 |
- Ksia, Mingyu
- Zhao, Ksiaofeng
- Dzhiang, Ksyunlej
- Dzhiang, Ksyundong
|
RU2768583C2 |
| COMBINATIONS (COMPOSITIONS), INCLUDING DMXAA FOR CANCER TREATMENT |
2006 |
- Grin Kolin
- Kelland Llojd
- Roulinson-Basza Gejl
|
RU2404765C2 |
| ONCOINHIBIN, METHOD OF ITS PREPARING AND ONCOINHIBIN-CONTAINING PHARMACEUTICAL COMPOSITION |
1993 |
|
RU2139087C1 |
| N-QUINOLYL- OR ISOQUINOLYL-SUBSTITUTED PURINE DERIVATIVES, METHODS FOR PREPARING AND USING THEREOF |
2006 |
|
RU2417230C2 |
| PROCASPASE COMBINED THERAPY WITH GLYBLASTOMA |
2013 |
- Paul J. Hergenrother,
- Rachel C. Botham,
- Timothy M. Fan,
- Mark J. Gilbert,
- Michael K. Handley,
- Theodore M. Tarasow,
- Avadhut Joshi,
- Gregory J. Riggins,
|
RU2636234C2 |
| PHARMACEUTICAL COMPOSITION FOR INHIBITION OF INTERLEUKIN-2- -DEPENDENT TUMOR CELLS PROLIFERATION, γ--INTERFERON CONTENT INCREASE, TREATMENT OF PATIENTS WITH INTESTINE INFLAMMATORY DISEASES, INHIBITION POTENTIATION OF CYTOKINE PRODUCTION AND LIMITATION OR INHIBITION OF ALLERGIC RESPONSE OF DELAYED TYPE |
1993 |
- Robert Koffmen
- Jan De Fris
- Rene Dee Vaal' Malefit
- Fiona Pauri
- Dona Rennik
|
RU2120802C1 |
| THE USE OF CARRIMYCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PRODUCTION OF MEDICINES FOR TREATMENT AND / OR TUMOR PREVENTION |
2018 |
- Dzhiang, Enkhong
- Ksia, Mingyu
- Dzhiang, Ksyunlej
- Dzhiang, Ksyundong
|
RU2746047C1 |
| COMBINATIONS OF ANTIFOLATE AGENT IN CANCER TREATMENT |
2007 |
- Tojer Charl'Z P.
- Adams Bonn Zhan
|
RU2423114C2 |
