COMBINATIONS OF ANTIFOLATE AGENT IN CANCER TREATMENT Russian patent published in 2011 - IPC A61K31/13 A61K31/519 A61P35/00

Abstract RU 2423114 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed is application of first composition, containing pemetrexede and second composition, containing methoxyamine, for treatment of patient with diagnosed cancer, selected from lung cancer, colorectal cancer, ovary cancer, pancreatic cancer, kidney cancer, endometrial cancer, stomach cancer, lover cancer and breast cancer.

EFFECT: methoxyamine enhanced, increased or potentiated chemotherapeutic effect of antifolate anti-cancer agent; also demonstrated is unexpected reversing resistance to pemetrexede.

16 cl, 8 dwg,1 tbl

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RU 2 423 114 C2

Authors

Tojer Charl'Z P.

Adams Bonn Zhan

Dates

2011-07-10—Published

2007-12-21—Filed