FIELD: medicine.
SUBSTANCE: one or more genetic makers containing a gene of a MGMT enzyme mutant form (O6-methylguanine DNA-methyltransferase) resistant to O6-benzylguanine inhibitor inhibiting action of a MGMT natural form, and also a nucleotide sequence exhibiting therapeutic action are introduced into cells. The cells modified in such a way are transplanted into a body, thereafter said inhibitor, and then lysomustine isomer 2 or mixed lysomustine isomers 1 and 2 which inhibit autologous cell reproduction thereby inducing modified cell selection are introduced in the body.
EFFECT: invention provides more effective selection of the modified cells and allows higher safety and efficiency of the method of cell selection ensured by using lysomustine characterised by lower toxicity.
4 cl, 9 dwg, 1 ex
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