PEPTIDE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF THROMBIN INHIBITION IN MAMMAL Russian patent published in 2000 - IPC

Abstract RU 2148585 C1

FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to peptide derivative of the general formula (I): X-Y-NH-(CH₂)₂-G or its pharmaceutically acceptable salt or its solvate where values X, Y, r, G are given in p. 1 of the invention claim. Compounds can be used for inhibition of thrombin activity in mammal. Invention describes also method of synthesis of these peptides, pharmaceutical composition and method of inhibition of thrombin activity in mammal. EFFECT: improved method of synthesis and thrombin inhibition. 6 cl, 2 tbl, 92 ex

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RU 2 148 585 C1

Authors

Smit Dzheral'D Flojd

Uili Majkl Robert

Shakht Aaron Lejg

Shuman Robert Teodor

Dates

2000-05-10—Published

1995-03-03—Filed