FIELD: pharmaceutical chemistry. SUBSTANCE: invention, in particular, relates to non-steroid compounds of formula II: 
(II), wherein R4,R5,R6,R7,R8 are defined in claims, or pharmaceutically acceptable salt thereof, whose hysterotrophic effect is minimized by simultaneously or successively introducing compound of formula I: 
(I), wherein R1,R2,R3 are defined in claims, or pharmaceutically acceptable salt thereof. Resulting pharmaceutical composition is adequate for treating or preventing mammary gland cancer. EFFECT: enhanced antineoplastic properties and minimized harmful hysterotrophic effect. 11 cl, 1 tbl, 35 ex
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