FIELD: medicine, pharmacy. SUBSTANCE: invention relates to heparin-containing compositions showing antithrombotic activity and without any hemorrhagic activity. Compositions (S1, S2, S3) consist of heparin fractions obtained by neutralization of heparin with protamine in vitro. Invention relates to also method of preparing these compositions. These compositions are used for making drugs with acceptable carrier. The use of claimed compositions do not induce bleeding and they retain the main properties completely. EFFECT: improved method of preparing, enhanced curative effectiveness. 21 cl, 13 tbl, 2 dwg, 3 ex
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