NEW SULFONAMIDES Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: described are new sulfonamides of general formula I: wherein R¹ is hydrogen, lower alkyl; R² is hydrogen, lower alkyl; R³ is hydrogen, lower alkyl; R² and R³ are together methylene-dioxy, ethylenedioxy or ispropylidedinoxy: R⁴ is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, oxylower alkyl, oxylower alkoxy, oxylower alkoxy-lower alkyl, oxylower alkoxy-lower alkoxy, alkoxy-lower alkyl, alkoxy-lower alkoxy, amino-lower alkyl, lower alkyl amino-lower alkyl, morpholino, 2-pirimidinyl, CHO, -CH₂OH or -CH₂Cl;; R⁵-R⁸ are hydrogen, halogen, lower alkoxy, lower alkylthio; X is -O- or -S-; Y is -CHO; C_1-4 alkyl, and cyclic ketals thereof, , OR¹², R⁹ are hydrogen or C_1-4 alkyl; R¹² is C_1-4 -$ alkyl; or -(CH₂)_0-4-aryl; Z is -O-, het is heterocyclic residue such as thienyl, pyridinyl, hal is halogen, and n is 0 or 1. Compounds are essentially endotolialic receptor inhibitors and are useful for treating disease associated with processes which promote narrowing of vessels. EFFECT: improved properties of new sulfonamides. 13 cl, 56 ex, 2 tbl