PYRAZOLPYRIMIDINE DERIVATIVES Russian patent published in 2010 - IPC C07D487/04 A61K31/519 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel pyrazolpyrimidine derivatives of formula (I) where p is 0 or 1; R¹ and R² can independently represent H, halogen, lower alkyl, lower alkoxy, possibly substituted with one or more halogens or CF₃; R³ is lower alkyl, hydroxy-lower alkyl or NR^aR^b; R^a and R^b are independently selected from a group consisting of H; cycloalkyl containing 3-6 carbon atoms; phenyl; lower alkyl possibly substituted with one or more hydroxy, fluorine, C_3-6cycloalkyl, phenyl, pyridyl or NR^cR^d, where R^c and R^d are independently selected from H or lower alkyl; or where R^a and R^b together with the nitrogen atoms to which they are bonded can form a 5- or 6-member hetero-ring, possibly additionally containing 1 or 2 heteroatoms selected from O or N, and possibly substituted with lower alkyl or hydroxy-lower alkyl; R⁴ is H, Cl, lower alkoxy, cycloalkyl, containing 3-6 carbon atoms, or straight lower alkyl which is possibly substituted with one or more F; R⁵ is H; halogen or lower alkyl; as well as to their pharmaceutically acceptable salts.

EFFECT: invention also relates to pharmaceutical compositions based on these compounds and their use in preparing medicine for treating or preventing acute and/or chronic neurological disorders in which activation of mGluR2 is involved.

19 cl, 179 ex