FIELD: medicine, pharmacy. SUBSTANCE: invention relates to anti-inflammatory preparation for topical use that has nimesulide as an active component. Nimesulide is mixed with the base in dispersed state. Preferable amount of nimesulide is 0.1-5 wt.-%, pH value is 4-8. Mixture of components taken among the group including hydrophilic polymer, white Vaseline, oily substance, nonionic surface-active agent, alkaline compound and absorption enhancer can be used as the base. Preparation can be made as emulsion or ointment. Method of preparing the preparation involves the gradual addition of nimesulide finely milled particles to the base and its dispersing in the base by stirring. Preferable mean diameter size of nimesulide particles is 0.01-75 mcm. Preparation does not stain skin and provides skin safety. EFFECT: enhanced absorbing capability of preparation. 14 cl, 2 tbl, 10 ex
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