MEDICAL COMPOSITION FOR PERCUTANEOUS ABSORBTION, PRODUCT KEEPING MEDICAL COMPOSITION, AND PREPARATION FOR PERCUTANEOUS ABSORBTION CONTAINING IT Russian patent published in 2011 - IPC A61K31/485 A61K9/70 A61K47/38 A61K47/32 A61K47/34 A61P25/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a preparation for percutaneous absorption containing a medical composition for percutaneous absorption in which an active component selected from morphine and its salts, is mixed in such amount which matches with saturation solubility or more, with an excipients keeping an active ingredient, having fluidity at temperature approximately equal to human skin surface temperature, and at least a portion of the active ingredient is found as crystals. The preparation is applied to an intact skin of a back of a white rabbit cut by electric shaver for 72 o'clock; an available dose of the active component in one dose of the preparation makes 10 mg to 400 mg of morphine at the morphine base, and the plasma concentration of the active ingredient 24 hours and 48 hours after the preparation application in the conditions specified above makes in each case at least 40 ng/ml at the morphine base.

EFFECT: preparation for percutaneous absorption is capable to support blood morphine concentration for a log time at an effective level for at least 48 hours.

35 cl, 2 dwg, 6 tbl, 16 ex