(1,2,3-TRIAZOLYL)-1,2,3-OXADIAZOLE DERIVATIVES POTENTIATING NO-DEPENDENT ACTIVATION OF SOLUBLE FORM OF GUANYLATE CYCLAZE Russian patent published in 2000 - IPC

FIELD: chemical industry. SUBSTANCE: described are new chemical compounds, more particularly (1,2,3-triazolyl)-1,2,5-oxadiazole derivatives of general formula I wherein R is NH₁ or , and if R¹ is H, then R² is lower hydroxyalkyl, or if R¹ is lower alkyl, lower hydroxyalkyl, aryl, then R² is H, lower hydroxyalkyl or radical of general formula: -C(O)R³ wherein R³ is OH, NH₂ lower alkyl or lower alkoxy. Said derivatives potentiate NO-dependent activation of soluble form of p guanylate cyclaze. Said 1,2,3-triazol-1-yl)- 1,2,3-oxadiazole derivatives produce selective potentiating effect on NO-dependent activation of soluble form of p guanylate cyclaze, widen range of specific regulators of activity of soluble form of p guanylate cyclaze. EFFECT: improved properties of the title compounds. 14 cl, 1 tbl