RACEMIC OR OPTICALLY ACTIVE ESTER DERIVATIVES OF TRANS-APOVIN CAMINIC ACID Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: described are new racemic and optically active ester derivative of trans-apovin caminic acid of formula I: wherein R is hydrogen or group (a): wherein Z is C_1-4 alkyl optionally substituted aryl, aralkyl, heteroaryl or 14-eburnamenilic group, and n is integer of 2,3 or 4 and also pharmaceutically acceptable salts thereof. Also described are pharmaceutical compositions comprising said compounds, method of preparing said compounds and compositions, and method of medical treatment. New compounds of formula I have antioxidant antiischemic and antiamnesia activity and are useful for inhibition of peroxidation of lipids and for treatment or protection from ischemia and amnesia and for treatment of various degenerative neurological diseases, such as Altsheimer disease. EFFECT: improved properties of the title compounds. 22 cl