4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS Russian patent published in 2001 - IPC

Abstract RU 2163237 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel 4-aryl-1- phenylalkyl-1,2,3,6-tetrahydropyridines of the formula (I) where Y is CH or -N-; R1 is H, halogen, CF3; R2 is H, halogen, (C3-C4)-alkyl or (C1-C4)-alkoxy-group; R3 and R4 means H or (C1-C3)-alkyl; X means: a) (C3-C6)-alkyl, (C3-C6)-alkoxy-group or (C1-C4)-alkoxycarbonyl-(C3-C6)-alkoxy-group; b) (C3-C7)-cycloalkyl or c) substitute taken among the group including phenyl, phenoxy, benzyl, their salts, solvates or quaternary ammonium salts. Compounds of the formula (I) show neurotropic and neuro- -protective activity and can be used in medicine for treatment of patients with central nervous system diseases. Invention relates to also intermediate compounds of the formula where is halogen atom or CF3 and formula (i) where R1, R2, R3, R4 and Y have values indicated for compounds of the formula (I) and W means methylene or carbonyl group. EFFECT: improved method of synthesis, valuable medicinal properties. 11 cl, 1 tbl, 39 ex

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RU 2 163 237 C2

Authors

Domeniko Badone

Marko Baroni

Rozanna Kardamone

Zhaklin Furn'E

Umberto Gudzi

Alessandra Elmini

Dates

2001-02-20Published

1996-06-26Filed