COMPOUNDS WITH SULFAMOYL AND AMIDINE GROUP, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: present invention describes compounds of general formula I wherein Ar₁ is phenyl, naphthyl, quinolyl, isoquinolyl optionally substituted with chlorine, fluorine, alkyl, alkoxy or dialkylamino; Ar₂ is phenyl optionally substituted by chlorine, fluorine, alkyl or alkoxy, or thienyl; R₁ and R₂ are H or alkyl; is hydrogen or R₂ and form double bond or R₁ has no values, then N is attached to Ar₂; R₃ and R₄ are alkyl or form with N to which they are attached, pyrrolidine, piperidine or hexahydroazepine; Z₁ is C_1-12 alkylene optionally interrupted by C_5-7-cycloalkyl or phenyl; Q₁ is H, methyl, amino, hydroxy, dialkylamino, guanidino, alkyl guanidino, pyridyl, indolyl, alkyl-4-piperazinyl, aminoalkyl-N-alkylamino, alkoxycarbonylamino, carbamoyl, phenyl optionally substituted by alkoxy, or pyridyl, imidazolyl, indolyl or pyrrolidinyl; Q₂ and Q₃ is H or alkil, or Q₂ and Q₃ form together C_2-3-alkylene as pure enantiomers or mixtures thereof, and also pharmaceutically acceptable acid salts thereof. Compounds of formula I and pharmaceutically acceptable salts thereof are capable of being fixed on biological neuropeptide receptors Y (NPY), peptide from 36 amino acids having wide spectrum of physiological activity, more particularly with respect to central nervous system or cardiovascular system. EFFECT: improved properties of title compounds. 8 cl, 83 ex, 1 tbl