FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine of the formula (I) 
where Ar means pyrid-2-yl or phenyl possibly substituted with halogen atom, methyl or alkoxyl-group; R1 is CH3; R11 - H or R1 and R11 in common mean the group -(CH2)3; R2 - hydroxyl, alkoxyl, acylhydroxy, cyano-group, 
(other values see p. 1 of the invention claim) and also their salts that show an antagonistic activity to human NK3-receptors. EFFECT: improved method of synthesis, valuable pharmacological properties of compounds. 20 cl, 5 tbl, 59 ex
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Year |
Author |
Number |
| SUBSTITUTED HETEROCYCLIC COMPOUNDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
1996 |
- Ksav'E Ehmon-Al'T
- Izabell' Grossrieter
- Patrik Gel'
- Vinchentso Proietto
- Did'E Van Bruk
|
RU2157807C2 |
| BASIC TYPE TERTIARY AMIDES, METHODS OF PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPOUNDS |
1993 |
- Ksav'E Ehmon-Al'T
- Patrik Gejl'
- Vinchentso Proietto
- Didier Van Broek
|
RU2120436C1 |
| ARYLALKYLAMINES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1991 |
- Ksav'E Ehmon-Al'T[Fr]
- P'Er Guljauik[Fr]
- Vinchentso Proietto[It]
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|
RU2070196C1 |
| DERIVATIVES OF 1-BENZENESULFONYL-1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-ONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING IT |
1994 |
- Alen Di Mal'Ta
- Zhorzh Garsia
- Daniel' Mettefe
- Dino Nizato
- Rishar Ru
- Klodin Serradej-Legal'
|
RU2135477C1 |
| POLYCYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS, METHOD OF SYNTHESIS OF POLYCYCLIC AMINE-CONTAINING COMPOUNDS, CYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO NEUROKININ RECEPTORS |
1992 |
- Ksav'E Ehmond-Al'T[Fr]
- Patrik Gel'[Fr]
- Vensanzo Pruaetto[It]
- P'Er Gulauik[Fr]
|
RU2083574C1 |
| METHOD OF SYNTHESIS OF (-)-N-METHYL-N-[4-(PHENYL-4-ACETAMINOPIPERIDINE-1-YL)-2-(3,4- -DICHLOROPHENYL)-BUTYL]-BENZAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
1995 |
- Marsel' Deskamp[Be]
- Zhoehl' Radisson[Fr]
- Zhill' Ann-Arshar[Fr]
|
RU2097376C1 |
| N-ALKYLENEPIPERIDINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, OPTICALLY PURE DERIVATIVES OF N-ALKYLENEPIPERIDINE |
1992 |
|
RU2089547C1 |
| SUBSTITUTED 1-NAPHTHYLPYRAZOLE-3-CARBOXAMIDES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND INTERMEDIATE COMPOUNDS OF SYNTHESIS |
1994 |
- Bernar Labeehv
- Daniell Gjuli
- Fransis Zhanzhan
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- Rober Buazhgrehn
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RU2140912C1 |
| 4-ALKYLENEPIPERIDINE DERIVATIVES OR THEIR SALTS WITH MINERAL OR ORGANIC ACIDS, OR QUATERNARY AMMONIUM SALTS SHOWING ACTIVITY WITH RESPECT TO NEUROKININ SYSTEM, A METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
1992 |
- Ksav'E Ehmond-Al'T[Fr]
- Izabell' Grossriete[Fr]
- Vensanzo Pruaetto[It]
- Did'E Van Broekk[Be]
|
RU2099327C1 |
| ENANTIOMERS OF AROMATIC NITROGEN-CONTAINING DERIVATIVES AND THEIR SALTS WITH INORGANIC OR ORGANIC ACIDS AND A METHOD OF THEIR SYNTHESIS |
1990 |
- Ksav'E Ehmon-Al'T
- P'Er Guljauik
- Vinchentso Proietto
- Did'E Van Bruk
|
RU2114828C1 |
