FIELD: medicine, pharmacy, antibiotics. SUBSTANCE: water-soluble conjugate or its salt has polymixin B or its salt and dextran. It shows an anti-endotoxic activity that exceeds that of the parent polymixin B. The ratio of polymixin B IC50 value to its conjugate IC50 value is above 1.0. Invention claims the method of conjugate preparing. Polymixin B or its salt is subjected for interaction with dextran in an aqueous medium at pH from 9.3 to 10 and temperature from 30 C to 35 C. Invention claims the composition containing water-soluble conjugate. Conjugate has the enhanced anti-endotoxic activity and method exhibits the best reproducibility. Conjugate activity is 125% and above as compared with that of the natural polymixin B. Invention can be used for preparing preparations used in therapy of systemic inflammatory reaction syndrome and septic shock. EFFECT: enhanced effectiveness of conjugates. 13 cl, 3 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2121835C1 |
| 8-ARYL-1,7-NAPHTHYRIDINE AND PHARMACEUTICAL COMPOSITION HAVING ANTINIFLAMMATORY ACTIVITY | 1997 |
|
RU2174123C2 |
| ISOQUINOLINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1994 |
|
RU2144027C1 |
| NOVEL DIAMINOPYRIDINE DERIVATIVES | 2016 |
|
RU2730007C2 |
| ORGANIC COMPOUNDS | 2008 |
|
RU2489439C2 |
| TRISUBSTITUTED PHENYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1996 |
|
RU2164224C2 |
| PHARMACEUTICAL PRODUCTS CONTAINING BIPHOSPHONATES | 2004 |
|
RU2358739C2 |
| HARD DRUG FORM CONTAINING ACTIVE AGENT WITH DISGUISED TASTE | 2007 |
|
RU2437657C2 |
| MOLECULE CONTAINING spr0096 AND spr2021 | 2012 |
|
RU2636350C2 |
| MODIFIED CAPSULAR SACCHARIDE, METHOD FOR PRODUCTION AND USE THEREOF | 2008 |
|
RU2563808C2 |
