TRISUBSTITUTED PHENYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel trisubstituted phenyl derivatives of the formula (1s) where R_1s means hydroxyl, alkyl containing 1-4 carbon atoms or alkoxyl containing 1-4 carbon atoms; R_2s means hydroxyl or alkoxyl at 5- or 6-position and containing 1-4 carbon atoms being R_1s and R_2s are not hydroxyl simultaneously; and a) W_s means -CH₂CH₂-; R_3s means the group of the formula -COR_6s where R_6s means alkyl containing 1-4 carbon atoms, alkoxyl containing 1-4 carbon atoms or amino-group; R_4s means amino-group, alkylamino-group containing 1-4 carbon atoms, dialkylamino-group where each alkyl moiety has independently 1-4 carbon atoms, alkylcarbonylamino-group where alkyl moiety has 1-4 carbon atoms or alkoxycarbonylamino-group where alkoxyl moiety has 1-4 carbon atoms; or b) W_s means -CH₂CH₂-, -CH₂NH-, -CH₂O- or -CH=CH- being nitrogen or oxygen atom is bound with ring B; R_3s and R_4s in common with ring B form the system of condensed rings of the formula (as) and (bs) where symbol _ _ _ _ means the ordinary or double bond; R_9s means hydrogen atom, alkylthio- -group containing 1-4 carbon atoms, alkyl containing 1-4 carbon atoms, amino-, diacetylamino-, alkylamino-group containing 1-4 carbon atoms, hydroxyl, alkoxyl containing 1-4 carbon atoms or mercapto-group; Y_s/ means N or CR_11s where R_11s means hydrogen atom or alkoxycarbonyl where alkoxyl moiety has 1-4 carbon atoms; R_10s means hydrogen atom, alkyl containing 1-4 carbon atoms or dialkoxybenzyl where alkoxyl moieties have independently 1-4 carbon atoms; and Z means O or S and V means NH if symbol _ _ _ means ordinary bond and N if symbol _ _ _ means double bond under condition that if R_9s means hydroxyl or mercapto-group and Y_s means N then compounds exist in tautomeric form of the formula (Its) where means O or S, in free form or as salt form if these forms are possible for existing. Compounds are useful for treatment of patients with proliferative and/or inflammatory disorders and cancer. EFFECT: new compounds indicated above, valuable medicinal properties. 4 cl, 52 ex