DERIVATIVES OF CARBOXYLIC ACID AMIDES WITH HETEROCYCLIC SUBSTITUENTS AND COMPOSITION SHOWING ABILITY TO INHIBIT 5-HT- AND/OR alpfa- AND/OR alpfa- AND/OR alpfa- AND/OR α-RECEPTORS Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes derivatives of carboxylic acid amides with heterocyclic substituents of the general formula (I) α_2A including their pharmaceutically acceptable salts where q = 0, 1, 2, 3 or 4; α_2D means: a) halogen atom; b) unsubstituted alkyl group with from one to three carbon atoms or alkyl group substituted with one or some halogen atoms; c) alkoxyl-group with from one to three carbon atoms; d) alkylsulfonylhydroxy-group with from one to three carbon atoms or alkylsulfonylhydroxy-group substituted with one or some halogen atoms and indicated substituents D₂ can be both similar and distinct under condition that q = 2, 3 or 4; U means alkylene chain with from one to three carbon atoms; Q means biradical of the formula (IIa) or (IIb) R¹; V means a bond or alkylene chain with from one to three carbon atoms; X means alkylene chain with 0, 1 or 2 carbon atoms; R¹ means alkylene chain with from one to four carbon atoms under condition that total number of carbon atoms in X and = three or four; T means acyl residue of heterocyclic carboxylic acid, heterocyclic fragment (Het) that is presented by the following residues: 2-, 3- or 4-pyridyl, 2- or 3-thienyl, 2-, 3-, 4- or 8-quinolinyl and each of that can be unsubstituted or substituted with one or some substituents among the group including: a) halogen atom; b) alkyl-group with from one to three carbon atoms; c) alkoxyl-group with from one to three carbon atoms; d) alkylthiol-group with from one to three carbon atoms; e) amino- -group; f) 1-pyrrolyl-group. Compounds can present active substance of composition showing ability to inhibit 5-- and/or X¹- and/or X¹- and/or HT_1A- and/or α₁-receptors and containing therapeutically effective amount of compound of the formula (I) or its salt in common with pharmaceutically acceptable vehicle or carrier. EFFECT: new compounds indicated above, valuable pharmacological properties. 6 cl, 29 ex