FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of amine of the formula (I) where R - halogen atom, hydroxyl, C1-3-alkyl, C1-3-alkoxyl; Q - a residue of the formula (IIa) , (IIb) ; V - methylene or ethylene; X is C0-2-alkylene chain; X' is C1-4-alkylene chain; T - phenyl, pyridyl, pyrazinyl, benzo[b]furanyl, 1,4-benzodi-oxanyl, quinazolinyl possibly substituted with halogen atom, methoxyl or trifluoromethyl; m = 0 or 1, and their pharmaceutically acceptable salts which show high affinity to receptors 5-HT1 and D2. EFFECT: high affinity of compounds to receptors. 6 cl, 1 tbl, 28 ex
Title | Year | Author | Number |
---|---|---|---|
DERIVATIVES OF CARBOXYLIC ACID AMIDES WITH HETEROCYCLIC SUBSTITUENTS AND COMPOSITION SHOWING ABILITY TO INHIBIT 5-HT- AND/OR alpfa- AND/OR alpfa- AND/OR alpfa- AND/OR α-RECEPTORS | 1996 |
|
RU2169147C2 |
SULFIDES, SULFOXIDES OR SULFONES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID | 1994 |
|
RU2135467C1 |
TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AS INDIVIDUAL ENANTIOMERS, RACEMATES OR OTHER ENANTIOMER MIXTURES | 1994 |
|
RU2135472C1 |
DERIVATIVES OF 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND STEREOISOMERS, PHARMACEUTICAL COMPOSITION AND METHOD OF ATTACK SUPPRESSION | 1994 |
|
RU2136684C1 |
0 |
|
SU507241A3 | |
HETEROCYCLIC COMPOUNDS AS ANTAGONISTS OF 5-HT RECEPTORS, METHOD OF SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2124512C1 |
0 |
|
SU507242A3 | |
BENZENESULFONE DERIVATIVES AND MEDICINAL AGENT | 1999 |
|
RU2201922C2 |
DERIVATIVES OF AMINOPHOSPHONIC AND AMINOPHOSPHINIC ACIDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 1997 |
|
RU2181362C2 |
DERIVATIVES OF QUINAZOLINE | 2002 |
|
RU2302244C2 |
Authors
Dates
1999-09-10—Published
1994-09-01—Filed