NOVEL DERIVATIVES OF PYRAZOLE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pyrazole of the formula (I) where X₁ means group -NRR₁R₂ or group -OR₂; g₂-g₆ are similar or distinct and mean independently each of other hydrogen, halogen atom, C_1-4-alkyl, C_1-4-alkoxyl-group, trifluoromethyl-group or C_1-4-alkylthio-group; w₂-w₆ are similar or distinct and mean independently each of other hydrogen, halogen atom, C_1-4-alkyl, C_1-4-alkoxyl or trifluoromethyl-group under condition that at least one of substituents g₂-g₆ and one of substituents w₂-w₆ are distinct from hydrogen atom; R₁ means hydrogen atom or C_1-4- alkyl; R₂ is nonaromatic unsubstituted C_3-15-carbocyclic radical or that mono- or multisubstituted with C_1-4-alkyl; R₃ is hydrogen atom or group CH₂-R₆;; each of R₄ and R₅ means independently hydrogen atom or C_1-4-alkyl; or R₄ means hydrogen atom and R₅ and w₆ in common form ethylene radical; R₆ means hydrogen or if substituents g₂, g₃, g₄, g₅ and/or g_6/ are distinct from C_1-4-alkyl then R₆ means hydrogen atom, C_1-4-alkyl or C_1-5-alkoxyl, and to their salts. Invention relates to also method of synthesis of derivatives of pyrazole of the formula (I) and pharmaceutical composition containing thereof. New synthesized compounds are antagonists of CB₂ receptors and pharmaceutical composition has affinity to CB₂ receptors and they can be used for treatment of patients with autoimmune diseases. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal and pharmacological properties. 17 cl, 2 tbl, 59 ex