FIELD: genetic engineering of proteins, medicine, oncology, pharmacy. SUBSTANCE: invention relates to novel anti-EGFR antibodies and their single-chain Fv-fragments that can be prepared from library phage-antibody constructed from mammal immunized cells, preferably, from mouse. Two single-chain Fv isolated from library phage-antibody are treated by methods of genetic engineering to create molecules of partially humanized complete antibody. These chimeric anti-EGFR antibodies have constant regions of human immunoglobulins and can be used as well as their single-chain Fv as agents for diagnosis and treatment of humans with tumors. EFFECT: new antibodies indicated above, valuable medicinal properties. 9 cl, 5 tbl
| Title |
Year |
Author |
Number |
| ANTI-IDIOTYPICAL ANTIBODIES THAT INDUCE IMMUNE RESPONSE AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR |
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- Karsel'Er Ana
- Rosel' Ehlizabet
- Gomes Alisija
- Adan Khaume
- P'Julats Khaume
|
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- Karr Frehnsis Dzh.
- Karter Grehm
- Dzhons Tim
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- Khamil'Ton Anita
|
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- Shtrittmatter Vol'Fgang
- Jeggle Karlota-Sil'Via
- Mojer Shtefan
- Burkkhart Shraven
- Vil'D Martin
|
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| IMMUNOCONJUGATES, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION |
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- Vol'Fgang Khel'Tser
- Ilka Fon Khoegen
- Vol'Fgang Shtrittmatter
- Zigfrid Mattsku
|
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- Ilka Fon Khegen
- Uve Khofmann
- Karlotta-Sil'Vija Eggle
- Vol'Fgang Shtrittmatter
- Jorg Shtadl'Mjuller
- Zigfrid Mattsku
|
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- Mateus Zuzanne
- Maler Khanns-Kristian
|
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- Mateus Zuzanne
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|
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- Krejsh Khans-Georg
- Shmidt Jurgen
|
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- Mitkhans Fransesk
- Piulats Khaume
- Rosel' Ehlizabet
- Adan Khaume
- Gudman Sajmon
- Khan Dajane
|
RU2205223C2 |
| COMBINED THERAPY USING INHIBITORS OF TYROSINE KINASE RECEPTORS AND INHIBITORS OF ANGIOGENESIS |
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|
RU2292904C2 |
