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2 181 123

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IPC

(21) (22)

Application

96115341/04, 1996-07-19

(24)

Start date

1996-07-19

(22)

Actual filing date

1996-07-19

(45)

Published

2002-04-10

(72)

Inventor

Mattske Mikhaehl'Milittser Khans-KristianMittendorf JoakhimKunish FrantsShmidt Aksel'Shenfel'D Vol'FgangTsigel'Bauer Karl

(73)

Holder

Bajer Ag

PHARMACEUTICAL COMPOSITION WITH FUNGICIDE ACTIVITY AND DERIVATIVES OF DIPEPTIDE OF ALPHA-AMINO ACID OR ITS DERIVATIVE AND CYCLOPENTANE-BETA-AMINO ACID OR ITS DERIVATIVE Russian patent published in 2002 - IPC

Abstract RU 2181123 C2

FIELD: organic chemistry, amino acids, pharmacy. SUBSTANCE: invention relates to the composition with antifungal activity containing at least one cyclopentane-beta-amino acid and/or its derivative of the general formula (Ib) where R¹ and R² in common mean residue of the formula =CH₂; R⁶ and Y mean hydrogen atom and at least one alpha-amino acid and/or its derivative of the formula (Ia) additionally where R³ means linear or branched C₁-C₈-alkyl; R⁴ and R⁵ means hydrogen X means hydroxyl and alpha-amino acid and/or its derivative and cyclopentane-beta- amino acid and/or its derivative are taken in the molar ratio from 1: 1 to 1:5. Invention relates to also dipeptide of the general formula (A) where R¹-R⁶ are given above; X and Y mean a moiety of covalent bond of alpha-amino acid and cyclopentane-beta-amino acid. Invention relates to also a pharmaceutical composition with antifungal activity containing at least one dipeptide of the formula (A) as an active substance taken in effective amount and nontoxic pharmaceutically inert carrier. EFFECT: valuable antifungal properties of composition. 4 cl, 1 tbl, 7 ex

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RU 2 181 123 C2

Authors

Mattske Mikhaehl'

Milittser Khans-Kristian

Mittendorf Joakhim

Kunish Frants

Shmidt Aksel'

Shenfel'D Vol'Fgang

Tsigel'Bauer Karl

Dates

2002-04-10—Published

1996-07-19—Filed