AMINO ACID DERIVATIVES, METHOD OF PRODUCING SAID DERIVATIVES, USE THEREOF AND PHARMACEUTICAL COMPOSITION Russian patent published in 2010 - IPC C07C229/34 C07C229/36 C07C227/12 C07C271/22 A61K31/195 A61K31/198 A61P7/00 A61P37/00 

Abstract RU 2379281 C2

FIELD: chemistry.

SUBSTANCE: described is a compound of formula I , where R1 is C1-C6alkyl; R2 is a radical of formula a, where R6 is C1-C12alkyl, R7 is H, X is O, R3 is -A-B-COOH, where A and B each independently represents a chemical bond, or CDE, where D and E each independently represents H, and each R4 and R5 independently represents H, under the condition that, if R4 is H, R5 is H, R3 is COOH, R2 is a radical of formula a, and R7 is H, R1 is CH3, and XR6 is an unsubstituted OC1-C12alkyl radical, then XR6 is not in the meta-position to (CH2)2-CR1R3(NR4R5), in free form or in form of a pharmaceutically acceptable salt, as well a production method and use thereof primarily during transplantation, as well as pharmaceutical composition containing said compounds.

EFFECT: new compounds have useful biological properties.

7 cl, 3 ex

Similar patents RU2379281C2

Title Year Author Number
DERIVATIVE OF α-AMINOHYDROXAMIC ACID, METHOD FOR ITS PREPARING AND PHARMACEUTICAL COMPOSITION 2000
  • Brajtenshtajn Verner
  • Khajaakava Kendzhi
  • Ivasaki Gendzhi
  • Kanazava Takanori
  • Kasaoka Tatsukhiko
  • Koizumi Shinichi
  • Matsunaga Shinichiro
  • Nakadzhima Motovo
  • Sakaki Junichi
RU2265592C2
COMPOUNDS HAVING ARYLSULPHONAMIDE STRUCTURE, USED AS METALLOPROTEASE INHIBITORS 2008
  • Rossello Armando
  • Nuti Ehliza
  • Orlandini Ehlizabetta
  • Bal'Zamo Al'Do
  • Tuchchinardi Titsiano
RU2488580C2
INDOLYLMALEIMIDE DERIVATIVES 2005
  • Van-Ehjs Mauris
  • Fon-Matt Peter
  • Vagner Jurgen
  • Ehvenu Zhan-P'Err
RU2373201C2
DERIVATIVES OF DOLASTATIN 10 2002
  • Fudzhi Toshiko
  • Okada Takekhiro
  • Taniguchi Mikio
  • Vatanabe Fumio
RU2296750C2
INDOLYLMALEIMIDE DERIVATIVES, METHOD OF THEIR OBTAINING, THEIR APPLICATION AND PHARMACEUICAL COMPOSITION FOR TREATMENT OR PREVENTION OF T-LYMPHOCYTE AND/OR "ПКС"- MEDIATED DISORDERS OR DISEASES 2003
  • Ehvenu Zhan-P'Er
  • Fon-Matt Peter
  • Vagner Jurgen
  • Tsenke Gerkhard
RU2340610C2
METHOD FOR SYNTHESIS OF EPOTHILONE DERIVATIVES, NOVEL EPOTHILONE DERIVATIVES, AS WELL AS NOVEL INTERMEDIATE COMPOUNDS FOR REALISING SAID METHOD AND SYNTHESIS METHODS THEREOF 2003
  • Kokh Guido
  • Lauzeler Oliv'E
RU2404985C2
CONDENSING DICYCLIC NITROGEN CONTAINING HETEROCYCLES, WHICH HAVE DGAT INHIBITING ACTION 2003
  • Foks Brajan M.
  • Furukava Noboru
  • Khao Sjaolin'
  • Ijo Kijosej
  • Inaba Takasi
  • Dzhekson Sajmon M.
  • Kajzer Frank
  • Label' Mark
  • Li Kehsjueh
  • Matsui Takuja
  • Makminn Dastin L.
  • Ogava Nobuja
  • Rubenshtejn Stiven M.
  • Sagava Soiti
  • Sugimoto Kazujuki
  • Suzuki Masakhiro
  • Tanaka Masakhiro
  • E Gosehn'
  • Josida Atsukhito
  • Chzhan Tszjan'
RU2342388C2
METHOD OF OBTAINING EPOTILONE DERIVATIVES 2003
  • Kokh Guido
  • Luazeler Oliv'E
RU2343155C2
MACROCYCLIC PYRIDAZINONE DERIVATIVES 2014
  • Zhoran-Lebryun Katrin
  • Kulkarni Santosh
  • Kristmann-Frank Serzh
RU2660435C2
DERIVATIVES OF BENZIMIDAZOL, COMPOSITIONS CONTAINING THEM, OBTAINING AND APPLICATION 2004
  • Liu Ziping
  • Pazhe Daniel'
  • Uolpol Kristofer
  • Jang Khua
RU2346938C2

RU 2 379 281 C2

Authors

Khinterding Klaus

Khegenauer Klemens

Dates

2010-01-20Published

2005-03-08Filed