FIELD: chemistry.
SUBSTANCE: described is a compound of formula I , where R1 is C1-C6alkyl; R2 is a radical of formula a, where R6 is C1-C12alkyl, R7 is H, X is O, R3 is -A-B-COOH, where A and B each independently represents a chemical bond, or CDE, where D and E each independently represents H, and each R4 and R5 independently represents H, under the condition that, if R4 is H, R5 is H, R3 is COOH, R2 is a radical of formula a, and R7 is H, R1 is CH3, and XR6 is an unsubstituted OC1-C12alkyl radical, then XR6 is not in the meta-position to (CH2)2-CR1R3(NR4R5), in free form or in form of a pharmaceutically acceptable salt, as well a production method and use thereof primarily during transplantation, as well as pharmaceutical composition containing said compounds.
EFFECT: new compounds have useful biological properties.
7 cl, 3 ex
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Authors
Dates
2010-01-20—Published
2005-03-08—Filed