FIELD: medicine pharmacy. SUBSTANCE: invention proposes a combination for treatment of patients with depression which involves mirtazapine or its pharmaceutically acceptable salt and one or some selective inhibitors of serotonin reuptake or their pharmaceutically acceptable salts. Pharmaceutical composition involves the combination of indicated components and one or more pharmaceutically acceptable carriers. Method of treatment of depressive patients is performed by administration of therapeutically effective dose of the combination or composition. EFFECT: enhanced effectiveness of combination and method of treatment. 7 cl, 2 ex
