SULFONAMIDES AND METHODS OF THEIR SYNTHESIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes sulfonamides of the general formula (I) where X means C₃-C₉-alkylene group; R² means H or C₁-C₃-alkyl; R¹¹ means H or C₁-C₃- alkyl; p = 0 or 1; q = 0-3; R¹² means phenyl or naphthyl optionally substituted with halogen atom, methoxy-group or trifluoromethyl-group, 4-biphenyl, cyclohexyl or adamantyl and R¹³ is taken independently among H, methyl and phenyl, and to methods of their synthesis. Compounds of the formula (I) are ligands of H₃- receptors of histamine and can be used as sedative agents, sleep regulators, anticonvulsant agents, antidepressants and modulators of brain blood circulation and for treatment of patients with asthma and irritable bowel syndrome also. EFFECT: improved method of synthesis, valuable medicinal properties. 10 cl, 1 tbl