SUBSTANCE KF-1040, METHOD OF ITS PREPARING AND STRAIN GLIOCLADIUM SPECIES SHOWING CAPACITY TO PRODUCE ITS Russian patent published in 2002 - IPC

Abstract RU 2184740 C2

FIELD: organic chemistry, biochemistry, medicine, microbiology. SUBSTANCE: invention relates to the novel substance KF-1040 comprising the substance KF-1040A presented by the formula (I) and the substance of the formula KF-1040B presented by the formula (II) and a method of its preparing. Method involves culturing microorganism of the strain Gliocladium sp. FERM BP-62516 that is able to produce substances KF-1040A and KF-1040B. This results to accumulation of these substances KF-1040A and/or KF-1040B in liquid culture and these substances are isolated from culture. The above mentioned substances are able to inhibit activity of diacylglyceroltransferase and sphingomyelinase and therefore they are useful for prophylaxis and treatment of atherosclerosis, obesity, thrombosis, inflammation and diseases associated with disorders of immune function. EFFECT: new substance indicated above, valuable biochemical and medicinal properties. 3 cl, 8 dwg, 1 tbl, 1 ex

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RU 2 184 740 C2

Authors

Omura Satosi

Tomoda Khirosi

Masuma Rokuro

Dates

2002-07-10—Published

1998-02-16—Filed