FIELD: chemical technology. SUBSTANCE: invention describes the improved method of purification of the known compound, cis- dichloroamminisopropylaminplatinum (II) used as a component of antitumor drugs. Rough salt containing impurities cis-[Pt(NH3)2Cl2] and cis-[Pt(iC3H7NH2)Cl2 taken in concentration 0.12-0.15 mole/l is dissolved in ammonium chloride an aqueous solution at 75-85 C and mass ratio liquid : solid substance = (20-25) : 1. Then solid ammonium oxalate is added in the amount providing its mole ratio to platinum = (4-5) : 1. Impurities are filtered off and filtrate is treated with concentrated hydrochloric acid at the room temperature. The yield of the end product is 60%, impurities content is less 1%. EFFECT: improved method of purification. 2 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF CIS-DICHLOROAMMINISOPROPYLAMINEPLATINUM (II) | 1995 |
|
RU2086559C1 |
| METHOD FOR PRODUCTION OF CIS-DICHLOROAMMINISOPROPYLAMINE PLATINUM(II) | 2006 |
|
RU2309158C1 |
| METHOD OF PRODUCING CIS-DICHLORODI(ETHYLAMINE)PLATINUM (II) | 2007 |
|
RU2361817C1 |
| METHOD OF CIS-DICHLORODIMETHYLAMINOPLATINUM (II) OBTAINMENT | 2007 |
|
RU2370447C2 |
| METHOD OF OBTAINING CIS-DICHLORODIISOPROPYLAMINEPLATINUM (II) | 2007 |
|
RU2360866C1 |
| METHOD FOR PREPARING POTASSIUM OR AMMONIUM TRICHLOROAMMINE PLATINATE (II) FROM CIS-DICHLORODIAMMINE PLATINUM (II) | 2005 |
|
RU2303571C2 |
| METHOD OF OBTAINING ISOMERS OF AMMINEPLATINUM (II) DICHLORIDE FROM MAGNUS' SALT | 2006 |
|
RU2329952C1 |
| METHOD TO MANUFACTURE POTASSIUM TRICHLOROAMMINEPLATINATE (II) OR AMMONIUM TRICHLOROAMMINEPLATINATE (II) FROM POTASSIUM TETRACHLOROPLATINATE (II) | 2006 |
|
RU2323886C2 |
| METHOD OF OBTAINING OF STERILISED MICROCRYSTALLIC SALT OF CIS-DICHLOROAMMINIZOPROPYLAMINPLATINUM (II) | 2007 |
|
RU2340347C2 |
| METHOD OF PRODUCING TRANS-DICHLOROMETHYLAMINE ISOPROPYLAMINE PLATINUM (II) | 2011 |
|
RU2464231C2 |
