METHOD OF SYNTHESIS OF CIS-DICHLOROAMMINISOPROPYLAMINEPLATINUM (II) Russian patent published in 1997 - IPC

Abstract RU 2086559 C1

FIELD: chemical technology. SUBSTANCE: method involves addition of oxalate ions to solution of potassium tetrachloroplatinate (II) and mixture is treated successively with solutions of ammonia, isopropylamine and hydrochloric acid. Cis-dichloroamminisopropylamineplatinum (II) prepared by this method does not contain impurity of cis-dichlorodiamminplatinum (II), cis-dichlorodiisopropylamineplatinum (II) and potassium chloride. The yield of the end product is 47%. Synthesized pure cis-dichloroamminisopropylamineplatinum (II) is used in medicine as antitumor drug of the II-d and III-d generations. EFFECT: improved method of synthesis.

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RU 2 086 559 C1

Authors

Kazbanov V.I.

Kozhukhovskaja G.A.

Starkov A.K.

Dates

1997-08-10Published

1995-06-06Filed