FIELD: medicine, immunology, nephrology, pharmacy. SUBSTANCE: method involves the combined administration to a patient cyclosporine or tacrolimus and pentozane polysulfate or its pharmaceutically acceptable salt. An oral route of administration is preferable. The total daily dose of pentozane polysulfate or its salt is in the range from 2 to 50 mg/kg of patient body weight or from 140 to 3500 mg per a day for adult. Invention proposes also a method of an immunosuppressive therapy ensuring to avoid nephrotoxicity induced by cyclosporine or tacrolimus and for these aims pharmaceutical compositions are proposed. Invention provides the prophylaxis of an immunosuppression said. EFFECT: improved method of prophylaxis. 42 cl, 6 dwg, 1 tbl
