FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a chimeric antigenic receptor (CAR) that elicits an antigen-specific response against CD22 when binding CAR to CD22, a nucleic acid encoding it, as well as a vector and a host cell containing said nucleic acid. Also disclosed is a pharmaceutical composition for treating or preventing cancer in a mammal, as well as a method of treating or preventing cancer in a mammal using said CAR. Invention also relates to the use of said host cell for the manufacture of a medicament for the treatment or prevention of cancer, where the cancer expresses CD22, as well as for the manufacture of a composition for detecting cancer, where the cancer expresses CD22.
EFFECT: invention enables to effectively treat or prevent cancer in a mammal.
31 cl, 6 dwg, 3 tbl, 7 ex
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