METHODS OF TREATING MYCOBACTERIAL INFECTIONS USING TETRACYCLINE COMPOUNDS Russian patent published in 2024 - IPC A61K31/427 A61K31/497 A61K31/5377 A61P31/04 A61P31/06 A61P31/08 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method of treating or preventing a mycobacterial infection in a subject in need thereof, comprising administering to said subject an effective amount of a tetracycline compound or a pharmaceutically acceptable salt or ester thereof, wherein said tetracycline compound is omadacycline, thereby providing treatment or prevention of said mycobacterial infection in said subject, where said mycobacterial infection is caused by non-tuberculosis mycobacteria (NTM), where said NTM belongs to a mycobacteria species selected from a group consisting of the following types: M. abscessus, M. chelonae and M. fortuitum, also relates to a method of treating or preventing a mycobacterial disease in a subject in need thereof, comprising administering to said subject an effective amount of a tetracycline compound or a pharmaceutically acceptable salt or ester thereof, wherein said tetracycline compound is omadacycline, thereby providing treatment or prevention of said mycobacterial disease in said subject, where said mycobacterial infection is caused by non-tuberculosis mycobacteria (NTM), where said NTM belongs to a mycobacteria species selected from a group consisting of the following types: M. abscessus, M. chelonae and M. fortuitum, also relates to a method of controlling or reducing the prevalence, severity or manifestations of a mycobacterial disease in a subject in need thereof, comprising administering to said subject an effective amount of a tetracycline compound or a pharmaceutically acceptable salt or ester thereof, wherein said tetracycline compound is omadacycline, as a result of which the inhibition of said mycobacterial disease in said subject or reduction in the prevalence, severity or manifestations of said mycobacterial disease in said subject, where said mycobacterial infection is caused by non-tuberculosis mycobacteria (NTM), where said NTM belongs to a mycobacteria species selected from a group consisting of the following types: M. abscessus, M. chelonae and M. fortuitum, also relates to a method of treating or preventing a mycobacterial infection in a subject in need thereof, comprising administering to said subject an effective amount of a tetracycline compound or a pharmaceutically acceptable salt or ester thereof, wherein said tetracycline compound is omadacycline, wherein said mycobacterial infection is caused by non-tuberculosis mycobacterium (NTM) belonging to the species M. abscessus.

EFFECT: group of inventions provides an effective method of treating or preventing mycobacterial infections.

23 cl, 3 dwg, 15 tbl, 6 ex