FIELD: molecular biology, genetic engineering, medicine. SUBSTANCE: DNA sequence encoding the novel antagonist of interleukin-1 receptor (ic IL + 1raII) is characterized. By insertion of this sequence in vector plasmid pSF5 and transformation of COS-cells with constructed expressing vector the expression of recombinant polypeptide with molecular mass about 25 kDa is achieved. Polypeptide shows inhibitory activity with respect to IL-Ia and IL-1b that is comparable with activity of intercellular form of antagonist of interleukin-1 receptor icIL + 1ra. Invention describes the use of novel antagonist of receptor IL-1 as active component in pharmaceutical composition used in pathologies associated with IL-1 producing. EFFECT: valuable medicinal properties of antagonist. 8 cl, 8 dwg, 1 ex
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Year |
Author |
Number |
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1993 |
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1995 |
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1990 |
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1992 |
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2023 |
- Aksenova Anna Yurevna
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