FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel compounds, namely, 2-acetyliminocoumarin-3-carboxylic acid 2,4-xylidide and m-phenetidide of the general formula: 
where 1a) R is 2,4-(CH3)2C6H3; 1b) R is m-C2H5OC6H4 that show anticoagulating activity and can be used in medicine. Index of anticoagulating effect of these compounds is higher by 5- and 5.6-fold as compared with that in the known preparation neodicoumarin and their toxicity is lower by 3.4- and 3.16-fold as compared with neodicoumarin, respectively. EFFECT: improved and valuable properties of compounds. 1 tbl
| Title |
Year |
Author |
Number |
| 6-NITRO-2-IMINOCOUMARIN 3-CARBOXYLIC ACID 4-TOLUIDIDE SILVER SALT ELICITING ANTIBACTERIAL ACTIVITY |
2003 |
- Ukhov S.V.
- Kon'Shin M.E.
- Novikova V.V.
- Odegova T.F.
- Syropjatov B.Ja.
|
RU2247119C1 |
| 1-ARYL-7-METHYL-2-[β-(5'-NITRO-2'-FURYL)VINYL]-PYRIDO[2,3-D]- PYRIMIDINE-4-ONES SHOWING ANTIBACTERIAL ACTIVITY |
1999 |
- Gavrilov M.Ju.
- Novoselova G.N.
- Rudometova E.V.
- Kon'Shin M.E.
|
RU2148580C1 |
| QUINOLINO [2,1-b] QUINAZOLIN-12-ONE-5- CARBOXYLIC ACID CYCLOHEXYLAMIDE HAVING ANTIFLAVIRAL ACTIVITY |
1997 |
- Mikhalev A.I.
- Jushkov V.V.
- Jushkova T.A.
|
RU2130023C1 |
| 2-CHLORO-5,6,7,8-TETRAHYDROQUINOLINE-4-CARBOXYLIC ACID 5-NITROFURFURYLIDENE HYDRAZIDE ELICITING AN ANTIBACTERIAL ACTIVITY |
1997 |
- Smirnova T.A.
- Gavrilov M.Ju.
- Novoselova G.N.
- Rudometova E.V.
- Kon'Shin M.E.
|
RU2127271C1 |
| 2-AMINO-5,6,7,8-TETRAHYDROQUINOLINE-3-CARBOXYLIC ACID 5-NITROFURFURYLIDENEHYDRAZIDE |
1998 |
- Gavrilov M.Ju.
- Novoselova G.N.
- Rudometova E.V.
- Kon'Shin M.E.
|
RU2136679C1 |
| N-BUTYLAMIDE 2-ANILINO-6,7-DIHYDRO-5H-PYRINDINE-3- CARBOXYLIC ACID HAVING ANTI-INFLAMMATORY ACTIVITY |
1997 |
- Galeeva R.N.
- Gavrilov M.Ju.
- Nazmetdinov F.Ja.
- Kolla V.Eh.
- Kon'Shin M.E.
|
RU2128651C1 |
| 2-OXO-1,2,5,6,7,8-HEXAHYDROQUINOLINE-4-CARBOXYLIC ACID ANILIDE SHOWING ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY |
1999 |
- Smirnova T.A.
- Gavrilov M.Ju.
- Vasiljuk M.V.
- Zaks A.S.
- Kon'Shin M.E.
|
RU2154061C1 |
| CITRACONIC ACID ISONICOTINOYLHYDRAZIDE ELICITING HYPOGLYCAEMIC ACTIVITY |
2000 |
- Dolzhenko A.V.
- Kolotova N.V.
- Koz'Minykh V.O.
- Kotegov V.P.
- Godina A.T.
- Syropjatov B.Ja.
- Russkikh V.A.
|
RU2183625C2 |
| N-SUBSTITUTED AMIDES OF 2-HYDROXY-4-OXO-4-(4-CHLOROPHENYL) 2-BUTENOIC ACID, EXHIBITING ANTIMICROBIAL ACTIVITY |
2009 |
- Mel'Nikova Natal'Ja Aleksandrovna
- Odegova Tat'Jana Fedorovna
- Borodin Anton Jur'Evich
- Igidov Nazim Musabekovich
- Chashchina Svetlana Viktorovna
- Borodina Tat'Jana Viktorovna
- Kirillova Rimma Valentinovna
|
RU2429225C2 |
| 9-BENZYLIDENEHYDRAZINO-1,2,3,4-TETRAHYDROACRIDINE SHOWING ANALGETIC AND ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS |
1999 |
- Dontsova L.P.
- Konshin M.E.
- Kolla V.Eh.
- Mardanova L.G.
- Novoselova G.N.
|
RU2161606C2 |
