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2 194 503

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IPC

(21) (22)

Application

2001130189/14, 2001-11-12

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Start date

2001-11-12

(22)

Actual filing date

2001-11-12

(45)

Published

2002-12-20

(72)

Inventor

Anan'Ev E.N.Velikanov V.P.Shabatin V.P.Jakutseni P.P.

(73)

Holder

Anan'Ev Evgenij NikolaevichVelikanov Viktor PavlovichShabatin Vladimir PetrovichJakutseni Pavel Pavlovich

COMPOSITE BASED ON CRYSTALLINE γ-MODIFICATION OF N- BUTYLAMINOBENZOIC ACID 2-DIMETHYLAMINOETHYL ESTER HYDROCHLORIDE EXHIBITING TOPICAL ANESTHETIC EFFECT Russian patent published in 2002 - IPC

Abstract RU 2194503 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: composite comprises pharmaceutical carrier and novel crystalline γ-modification of n-butylaminobenzoic acid 2-dimethylaminoethyl ester hydrochloride (dicaine). Crystalline γ-modification of dicaine exhibits melting point (149.5 ± 0.4) C and definite values of diffraction maxima and their relative intensities. The proposed composite as compared with composites based on the known modifications of dicaine ensures to prolong anesthesia period, decrease onset time of anesthesia being without by-side effects. Invention can be used in ophthalmology, microsurgery and stomatology as a topical anesthetic agent. EFFECT: valuable medicinal properties. 2 cl, 2 tbl

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RU 2 194 503 C1

Authors

Anan'Ev E.N.

Velikanov V.P.

Shabatin V.P.

Jakutseni P.P.

Dates

2002-12-20—Published

2001-11-12—Filed