GLYCYRRHIZIC ACID GLYCOPEPTIDE WITH S-BENZYL-L-CYSTEINE ELICITING ANTI-HIV ACTIVITY Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention describes novel compound and derivatives of glycyrrhizic acid, namely, glycyrrhizic acid glycopeptide with S-benzyl-L-cysteine: 3-O-{2-O-[N-β-D-gluco-pyranozyluronoyl)-L-cysteine-(S-benzyl)-N-(β-D-glucopyranozyl-uronoyl)-L-cysteine-(S-benzyl)]}-(3β, 20β)-11-oxo-olean-12-ene-30-(N-carbonyl-L-cysteine)-(S-benzyl)-3-yl showing anti-HIV activity. This compound exceeds glycyrrhizic acid by ability to inhibit virus-specific protein p24 (viral antigen) in using in equal concentrations (100 mcg/ml) in cultured cells MT-4 infected with the strain HIV-1/ and exceeds glycyrrhizic acid (IS = 4.4-24) by selectivity index (IS = 90). In concentration 100 mcg/ml anti-HIV activity of preparation is similar with activity of azidothymidine in curative dose but, in contrast to the latter, it shows less toxicity for MT-4 cells. EFFECT: enhanced activity, valuable medicinal properties of preparation. 1 tbl