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2 024 546

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IPC

(21) (22)

Application

4916056/04, 1991-03-04

(22)

Actual filing date

1991-03-04

(45)

Published

1994-12-15

(72)

Inventor

Tolstikov G.A.Baltina L.A.Pokrovskij A.G.Pljasunova O.A.Sandakhchiev L.S.

(73)

Holder

Institut Organicheskoj Khimii Unts Ran

β-GLYCYRRHIZIC ACID GLYCOPEPTIDE WITH L-GLUTAMIC ACID DIBUTYL ETHER SHOWING ANTI-AIDS-ACTIVITY Russian patent published in 1994 - IPC

Abstract RU 2024546 C1

FIELD: organic chemistry. SUBSTANCE: product: 3-O-[2-O- (N-b-D- glucopyranosyluranoyl-L- glutamic acid dibutyl ether)-N- b-D- glucopyranosyluranoyl-L- glutamic acid dibutyl ether]- (3b,20b -11,30-dioxo- (N-L-glutamic acid dibutyl ether)- 30-norolean -12-en, gross-formula is C81H131N3O25, yield is 64%, Rf = 0.5 (in CH3Cl:CH3OH:H2O = 45:10:1), value [α]2D

0 = +30 degree (c = 0.02 in CH3OH). Reagent 1: β-glycyrrhizic acid. Reagent 2: L-glutamic acid dibutyl ether. Reaction conditions: in the medium of dry dioxane in the presence of N-hydroxysuccineimide and N,N,N′-dicyclohexylcarbodiimide following by addition of dry triethylamine and dry dimethylformamide. EFFECT: improved method of synthesis. 1 tbl

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RU 2 024 546 C1

Authors

Tolstikov G.A.

Baltina L.A.

Pokrovskij A.G.

Pljasunova O.A.

Sandakhchiev L.S.

Dates

1994-12-15—Published

1991-03-04—Filed

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