FIELD: medicine, endocrinology, biochemistry, hormones. SUBSTANCE: invention relates to zinc-free insulin crystals with diameter less 10 mcm that are useful for administration by pulmonary route. Insulin powder shows reduced trend to associate and form aggregates in dry powder and therefore it is more stable in pulmonary delivery. Invention describes also therapeutic preparative form for treatment of diabetes mellitus and method of zinc-free insulin crystals preparing. EFFECT: improved properties of insulin crystals. 21 cl, 1 dwg
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