FIELD: medicine, endocrinology, hormones. SUBSTANCE: invention relates to insulin preparations with the excellent physical stability comprising dissolved and/or precipitated human insulin or its analogue, or its derivative and water-soluble reduced or non-reduced carbohydrate containing at least 4 carbon atoms in the basic carbohydrate structure, or water-soluble non-reducing ester and/or ether derivative of carbohydrate or reduced carbohydrate containing at least 4 carbon atoms in basic carbohydrate structure, or their mixture. Invention provides preparing the insulin preparation with enhanced physical stability. EFFECT: improved preparing method. 58 cl, 3 dwg, 1 tbl
