ANALOGS OF PARATHYROID GLAND HORMONE Russian patent published in 2003 - IPC

FIELD: medicine, biochemistry, hormones, peptides. SUBSTANCE: invention relates to peptide of the formula: where A₁ means Ser; A₃ means Ser or Aib; A₅ means Ile; A₇ means Leu or Cha; A₈ means Met or Nle; A₁₁ means Leu or Cha; A₁₂ means Gly or Aib; A₁₅ means Leu or Cha; A₁₆ means Asn or Aib; A₁₇ means Ser or Aib; A₁₈ means Met, Nle or Acc; A₁₉ means Glu or Aib; A₂₁ means Val; A₂₂ means Acc, Glu or Cha; A₂₃ means Trp, Acc, Cha or Leu; A₂₄ means Leu, Acc or Cha; A₂₇ means Lys, Leu, hArg, Ac or Cha; A₂₈ means Leu, Acc or Cha; A₂₉ means Glu, Gln or Aib; A₃₀ means Asp, Lys, Nle or Acc; A₃₁ means Val, Leu, Nle, Acc or Cha; A₃₂ means His; A₃₃ means Asn; A₃₄ means Phe, Tyr or Aib; each of radicals R₁ and R₂ means H independently each of other; and R₃ means NH₂ under condition that at least one of amino acid means Acc. Invention relates also to its pharmaceutically acceptable salt and these peptides are analogs of parathyroid gland hormone. Compounds show high binding degree with parathyroid hormone receptors and stimulate activity of adenylate cyclase. EFFECT: valuable medicinal and biochemical properties of peptides. 15 cl, 4 tbl