FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 5,8-dihydroxy-2,3,6-trimethoxy-7-ethyl-1,4-naphthoquine that is an intermediate product in synthesis of 2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone (echinochrome A) that is an active component of the preparation histochrome used as cardioprotective and ophthalmological agent. Invention describes method of synthesis of 5,8-dihydroxy-2,3,6-trimethoxy-7-ethyl-1,4-naphthoquinone by nucleophilic displacement of chlorine atoms in 5,8-dihydroxy-6,7-dichloro-3-ethyl-2-ethoxy-1,4-naphthoquinone by action with reagent MeOH-KF-Al2O3. Ethylene glycol dimethyl ester or diethylene glycol dimethyl ester are used as co-solvent. EFFECT: decreased time of synthesis process, increased yield of end product. 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF SUBSTITUTED 2,3,5,8-TETRAHYDROXY-1,4-NAPHTHOQIONONES | 1990 |
|
RU2022959C1 |
| METHOD FOR PREPARING 5,8-DIHYDROXY-2,6,7-TRIMETHOXY-3-ETHYL-1,4-NAPHTHOQUINONE | 2005 |
|
RU2277083C1 |
| METHOD FOR SPINOCHROME D PRODUCTION | 2016 |
|
RU2612265C1 |
| METHOD OF SYNTHESIS OF 2,5,8-TRIHYDROXY-6,7-DICHLORO-3-ETHYL-1,4-NAPHTHOQUINONE | 2001 |
|
RU2193550C1 |
| METHOD OF PRODUCING 6,7-SUBSTITUTED 2,3,5,8-TETRAHYDROXY-1,4-NAPHTHOQUINONES (SPINAZARINS) | 2012 |
|
RU2478607C1 |
| METHOD OF PRODUCING SPINOCHROME E | 2014 |
|
RU2561280C1 |
| METHOD OF PRODUCING 2,3,5,6,8-PENTAGHYDROXY-1,4-NAPHTHOQUINONE (SPINOCHROME D) AND INTERMEDIATE COMPOUNDS USED IN THIS METHOD | 2016 |
|
RU2632668C2 |
| METHOD OF PREPARING A CARBOHYDRATE-PROTEIN COMPLEX FROM JAPANESE SCALLOP | 1996 |
|
RU2121844C1 |
| METHOD OF PREPARING TRITERPENE GLYCOSIDE 3-0-D-GLUCOPYRANOSYL-((1-2)-L)-ARABINOPYRANOSIDE, HEDERAGENINE | 1994 |
|
RU2064934C1 |
| TEST FOR INTEGRAL EVALUATION OF SEA AND FRESH WATER POLLUTION STATE | 1997 |
|
RU2131925C1 |
