CYCLIC AMINO-DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF DISEASE PROPHYLAXIS Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to group of novel individual chemical compounds, namely to cyclic amino-compounds represented by the following formula (I): where R¹ means phenyl group that can be substituted optionally with at least one substituent representing halogen atom; R² means C₁-C₈-aliphatic acyl group or (C₁-C₄-alkoxy)-carbonyl group; R³ means saturated cyclic amino-group comprising from 2 to 8 carbon atoms in one or some cycles being the greatest nitrogen-containing cycle has from 3 to 7 atoms in cycle and indicated saturated cyclic amino-group is substituted with group of the formula S-X-R⁴ where R⁴ and X have values given below and indicated saturated cyclic amino-group is linked through its cyclic nitrogen atom to adjacent carbon atom to which substituents R² and R¹ are linked also; R⁴ means phenyl group that can be substituted optionally with at least one substituent taken among group consisting of halogen atoms, C₁-C₄-alkyl groups, C₁-C₄-alkoxyl groups and nitro-groups; C₁-C₆-alkyl group that can be substituted optionally with at least one substituent taken among group consisting of amino-groups, carboxyl groups, (C₁-C₄- alkoxy)-carbonyl groups, substituents of the formula NH-A¹ (where A¹ means α-amino acid residue) and substituents of the formula CO-A² (where A² means α-amino acid residue); or C₃-C₈- cycloalkyl group; X means sulfur atom, sulfyl group or sulfonyl group and the above mentioned cyclic amino-containing group can be substituted additionally but optionally with group of the formula =CR⁵R⁶ where R⁵ and R⁶ are similar or different and each means independently hydrogen atom, carboxyl group, (C₁-C₄-alkoxy)-carbonyl group, carbamoyl group, (C₁-C₄-alkyl)-carbamoyl group or di-(C₁-C₄-alkyl)-carbamoyl group; or their pharmacologically acceptable salts, pharmaceutical composition eliciting inhibitory effect on platelets aggregation; medicinal preparation containing amino-compound of the formula (I) and to method of prophylaxis of diseases taken among group consisting of embolism and thrombosis in warm-blooded animal. EFFECT: valuable medicinal properties of compounds. 30 cl, 7 tbl, 16 ex