FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to a compound of the structural formula (1), which possesses the activity increasing erythropoietin production. In formula
R1 represents a group of the structural formula
,
in which R4 and R5, each independently, represent a hydrogen atom, halogen atom or C1-C6alkyl group, R6 represents a hydrogen atom, halogen atom or C1-C6alkyl group, R7 represents a hydroxyC1-C6alkyl group, hydroxyhalogenC1-C6alkyl group, C1-C6alkoxyC1-C6alkyl group, which can have 1 substituent, independently selected from a group of substituents α, (C1-C6alkoxy)carbonyl group, C1-C6alkoxyC1-C6alkoxyC1-C6alkyl group, hydroxyC1-C6alkoxygroup, C1-C6alkylcarbamoyl group, (C1-C6alkyl)(C1-C6alkyl) carbamoyl group, (C1-C6alkyl)(C1-C6alkyl) carbamoylC1-C6alkyl group or C2-C7alkanoyloxyC1-C6alkyl group, α represents a hydroxygroup, Q1 ring represents a piperidinyl group, rings Q2 and Q3 represent a phenyl or pyridyl group, X represents a simple bond or methylene, R2 represents a C1-C3alkyl group and R3 represents a hydrogen atom.
EFFECT: invention relates to a pharmaceutical composition, containing the said compounds, to the application of a compound for obtaining a medication for the enhancement of erythropoietin production and to a method of treatment or prevention of a disease, caused by reduced erythropoietin production, such as anaemia.
33 cl, 1 tbl, 55 ex
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