DERIVATIVES OF BENZAMIDE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, biochemistry, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (I) where R¹ and R² mean hydroxy-, alkoxy-, amino-, alkylamino-, carboxy-group, alkoxycarbonyl, nitro-, cyano-group, cyanoalkyl, aminoalkyl, alkyl, halogen atom, trifluoro- methyl, heterocyclyl, heterocyclylalkyl; m and p = 0-3; q = 0-4; R³ means halogen atom; R⁴ means aryl or cycloalkyl. Invention relates to methods for their preparing that involves: a) interaction of compound of the formula (II) with acid of the formula (III) ; b) reaction of acid of the formula (V) with aniline of the formula (VII) . Except for, proposed compounds exhibit inhibitory activity with respect to cytokines and can be an active component of pharmaceutical composition. EFFECT: improved preparing method, valuable medicinal properties of compounds. 11 cl, 2 tbl