DERIVATIVES OF BENZAMIDE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of benzamide of the formula (I): wherein R³ represents (1-6C)-alkyl or halogen atom; Q represents aryl or heteroaryl that carries optionally 1, 2, 3 or 4 substituents taken among hydroxy-group, halogen atom, cyano- group, nitro-group, amino-group, carboxy-group, (1-6C)-alkyl, (2-6C)-alkenyl, (2-6C)-alkynyl, (1-6C)-alkoxy- group, (1-3C)-alkylenedioxy-group, (1-6C)-alkylamino-group and so on; R² represents (1-6C)-alkyl, (2-6C)- alkenyl, (2-6C)-alkynyl, (1-6C)-alkoxy-group, (1-6C)-alkylamino-group or di-[(1-6C)-alkyl]-amino-group; R⁴ represents aryl, aryl-(1-6C)-alkoxy-group, aryloxy-group, arylamino-group, cycloalkyl or heteroaryl; R⁴ carries optionally 1, 2, 3 or 4 substituents taken among halogen atom, cyano-group, (1-6C)-alkyl, (2-6C)-alkenyl, (2- 6C)-alkynyl, (1-6C)-alkoxy-group, (1-6C)-alkylamino-group and so on, or to its pharmaceutically acceptable salts, or to its ester cleft in vivo. Invention proposes methods for preparing derivatives of benzamide eliciting cytokine-inhibitory activity and containing active component and pharmaceutically acceptable excipient or carrier. As active component the pharmaceutical composition contains effective amount of benzamide derivative of the formula (I) or its pharmaceutically acceptable salt, or its ester cleft in vivo. Invention provides preparing derivatives of benzamide of the formula (I) used as inhibitors of disease mediated by cytokine. EFFECT: improved preparing method, valuable medicinal properties of compounds. 11 cl, 5 tbl, 37 ex