FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to derivatives of amide of the general formula (I)
wherein X means -CH; Y means -CH or nitrogen atom (N); m = 1 or 2; R1 means (C1-C6)-alkyl, (C1-C)-alkoxy-group, N,N-di-[(C1-C6)-alkyl]-amino-group, heterocyclyl-(C1-C6)-alkyl wherein heterocyclyl represents piperazinyl or homopiperazinyl; n = 3; R2 means halogen atom, (C1-C6)-alkyl; R3 means hydrogen atom; Q means phenyl optionally substituted with cyano-group, or pyridyl optionally substituted with morpholino-group, or their pharmaceutically acceptable salts, to methods for synthesis of indicated compounds, pharmaceutical compositions containing thereof and their using in treatment of diseases or states mediated by cytokines.
EFFECT: improved preparing methods, valuable medicinal properties of compounds and pharmaceutical compositions.
10 cl, 2 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AMIDE DERIVATIVES, METHOD FOR PRODUCTION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION AND INHIBITION METHOD | 2000 |
|
RU2260007C2 |
| DERIVATIVES OF BENZAMIDE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1999 |
|
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|
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|
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|
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| QUINAZOLINE DERIVATIVES, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION | 2001 |
|
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| QUINAZOLINE DERIVATIVES FOR TUMOR TREATMENT | 2001 |
|
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|
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| N-PHENYL-2-PYRIMIDINE DERIVATIVES | 2003 |
|
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| CYTOKINE INHIBITORS | 2004 |
|
RU2394029C2 |
