FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of acylpiperazinyl- pyrimidine of the general formula (I) 
where X means oxygen or sulfur atom; R1 means C1-C4-alkoxy-group, CF3; R2 means C1-C6-alkyl, saturated C3-C6-cycloalkyl; heterocycloalkyl with 3-6 ring atoms where heteroatom represents O, S or N atom optionally N-substituted with C1-C6-alkyl; phenyl optionally substituted with F, Cl, Br, NH2,CH3CF3 or OCH3; 5-6-membered heteroaryl with O, S or N as heteroatom that can be substituted or the condensed heteroaromatic system comprising 9 atoms. Compounds of the formula (I) exhibit activity with respect to the central nervous system and useful for treatment of sleep disorders and neurodegenerative diseases. EFFECT: valuable medicinal properties of compounds. 15 cl, 6 tbl, 1 dwg
